Postdoctoral Fellowship, at University of British Columbia (2010 - current).
Developing new methodologies and discovering new multifunctional molecules for Alzheimer's disease as a member of Prof. Chris Orvig's Group.
PhD in Chemistry, at Universitat Autònoma de Barcelona (September 4th 2009).
Thesis Title: “Agents quelants multifuncionals per a la malaltia d’Alzheimer”. Thesis advisor: Prof. Pilar González Duarte
M.Sc. in Chemistry at Universitat Autònoma de Barcelona (September 13th 2005).
Title; “Lligands quelants com agents de diagnosi en la malaltia d'Alzheimer" under supervision of Prof. Pilar González Duarte
B.Sc. in Chemistry at Universitat Autònoma de Barcelona (1998 – 2003)
Pedagogical Aptitude Certificate at Universitat Autònoma de Barcelona (2002-2003)
Developing new methodologies and discovering new multifunctional molecules for Alzheimer's disease as a member of Prof. Chris Orvig's Group.
PhD in Chemistry, at Universitat Autònoma de Barcelona (September 4th 2009).
Thesis Title: “Agents quelants multifuncionals per a la malaltia d’Alzheimer”. Thesis advisor: Prof. Pilar González Duarte
M.Sc. in Chemistry at Universitat Autònoma de Barcelona (September 13th 2005).
Title; “Lligands quelants com agents de diagnosi en la malaltia d'Alzheimer" under supervision of Prof. Pilar González Duarte
B.Sc. in Chemistry at Universitat Autònoma de Barcelona (1998 – 2003)
Pedagogical Aptitude Certificate at Universitat Autònoma de Barcelona (2002-2003)
Research Interests
My research interests are in the field of drug discovery and medicinal inorganic chemistry applied to neurodegenerative disorders, in particular Alzheimer’s disease. Within these areas, I find very attractive develop computational methods such as chemoinformatics and molecular modeling for the selection of drug-like candidates before proceed to experimental assays. In order to find a potential application in biological systems, evaluate selected drug-like compounds by means of biochemical assays and molecular imaging (PET, SPECT).
Professional Experience
Position
(2010 - current) Postdoctoral Researcher in the UBC
(2003 - 2009) Teaching Fellowship in the Department of Chemistry, Universitat Autònoma de Barcelona (UAB).
(2010 - current) Postdoctoral Researcher in the UBC
(2003 - 2009) Teaching Fellowship in the Department of Chemistry, Universitat Autònoma de Barcelona (UAB).
Research activities and collaborations
March 2007 – June 2007. Collaboration with Institut Químic de Sarrià (IQS) under supervision of Prof. Antoni Planas. Preparation of
transthyretin (TTR) amyloid fibrils and binding studies of TTR with intercalating molecules by means of fluorescence assays.
transthyretin (TTR) amyloid fibrils and binding studies of TTR with intercalating molecules by means of fluorescence assays.
February 2004 – June 2004. Collaboration with Consejo Superior de Investigaciones Científicas – Instituto de Investigaciones Químicas y
Ambientales de Barcelona (CSIC – IIQAB) under supervisión of Prof. Gemma Arsequell and Prof. Gregori Valencia. Investigation on
iodination reactions of aromatic compounds.
Ambientales de Barcelona (CSIC – IIQAB) under supervisión of Prof. Gemma Arsequell and Prof. Gregori Valencia. Investigation on
iodination reactions of aromatic compounds.
Teaching experience
September 2003 – September 2009. Laboratory courses for undergraduate students in Introduction to experimental chemistry and Inorganic
Synthesis. Tutoring sessions: First year of General Chemistry, Atomic Structure and chemical bonding, Principles in Inorganic Chemistry II and
Inorganic Chemistry Laboratories for fourth year students.
Credits in total: 63.75 (1 credit = 10 h)
Other positions
Synthesis. Tutoring sessions: First year of General Chemistry, Atomic Structure and chemical bonding, Principles in Inorganic Chemistry II and
Inorganic Chemistry Laboratories for fourth year students.
Credits in total: 63.75 (1 credit = 10 h)
Other positions
February 2003 – July 2003. Internship in industry during the education period carrying out analysis by Gas Chromatography (GC) and
High Performance Liquid Chromatography (HPLC).
Publications
Rodríguez-Rodríguez C., Rimola A., Rodríguez-Santiago, L., Ugliengo P., Álvarez-Larena A., Gutiérrez-de-Terán, H., Sodupe M.,
González-Duarte P. Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level.
Chem. Commun., 2010, 46(7), 1156-1158.
High Performance Liquid Chromatography (HPLC).
Publications
Rodríguez-Rodríguez C., Rimola A., Rodríguez-Santiago, L., Ugliengo P., Álvarez-Larena A., Gutiérrez-de-Terán, H., Sodupe M.,
González-Duarte P. Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level.
Chem. Commun., 2010, 46(7), 1156-1158.
Rodríguez-Rodríguez C., Sánchez de Groot N., Rimola A., Álvarez-Larena A., Lloveras V., Vidal-Gancedo J., Ventura S., Vendrell J.,
Sodupe M., González-Duarte P. Design, selection, and characterization of thioflavin-based intercalation compounds with metal
chelating properties for application in Alzheimer's disease.
J. Am. Chem. Soc., 2009, 131, 1436-1451
Rodríguez-Rodríguez C., Amigo J.M., Coello, J., Maspoch S. An Introduction to Multivariate Curve Resolution-Alternating Least Squares:
Spectrophotometric Study of the Acid-Base Equilibria of 8-Hydroxyquinoline-5-sulfonic Acid.
J. Chem. Ed., 2007, 84(7), 1190-1192
Sodupe M., González-Duarte P. Design, selection, and characterization of thioflavin-based intercalation compounds with metal
chelating properties for application in Alzheimer's disease.
J. Am. Chem. Soc., 2009, 131, 1436-1451
Rodríguez-Rodríguez C., Amigo J.M., Coello, J., Maspoch S. An Introduction to Multivariate Curve Resolution-Alternating Least Squares:
Spectrophotometric Study of the Acid-Base Equilibria of 8-Hydroxyquinoline-5-sulfonic Acid.
J. Chem. Ed., 2007, 84(7), 1190-1192
Conference Presentations
Oral communications
- Rodríguez-Rodríguez C., Sánchez de Groot N., Rimola A., Ventura S., Vendrell J., Sodupe M., González- Duarte P. Compuestos multifuncionales relevantes en la enfermedad de Alzheimer. XXXII Reunión Bienal de la Real Sociedad Española de Química, September 2009, Oviedo (Asturias, SPAIN)
- Rodríguez-Rodríguez C., Sánchez de Groot N., Rimola A., Álvarez, A., Lloveras, V., Vidal, J., Ventura S., Vendrell J., Sodupe M., González- Duarte P. A new strategy for Alzheimer's disease theragnosis: Integration of chelating properties into well known intercalation compounds. The First International Conference on Metal Chelation in Biology and Medecine, December 2009, Bath (United Kingdom)
- Rodríguez-Rodríguez C., Rimola A., Sodupe M., González-Duarte P. Agents de diagnosi per a la malaltia d’Alzheimer: compostos intercaladors amb propietats quelants. 5ª Trobada d’Investigadors dels Països Catalans, January 2008, Vic (Barcelona, SPAIN)
Poster communications
- Rodríguez-Rodríguez C., Rimola A., Sodupe M., González-Duarte P. The role of metal ions and metal ion chelators in Alzheimer’s disease. 13th International Conference on Biological Inorganic Chemistry (ICBIC13), July 2007, Vienna (AUSTRIA)
- Rodríguez-Rodríguez C., Arsequell G., González-Duarte, P., València G. Bioinformática,agentes quelantes y radiomarcaje: ¿Un posible diagnóstico para la enfermedad de Alzheimer?. 6ª Reunión de Química Inorgánica y del Estado Sólido (QIES06), September 2006, Barcelona (SPAIN)
- Rodríguez-Rodríguez C., Amigo J.M, Coello J., Maspoch Andrés S. Introducción a la resolución multivariante de curvas MCR-ALS. Estudio del equilibrio ácido-base del ácido sulfónico-8-hidroxiquinoleína 11ª Jornadas de Análisi Instrumental, November 2005, Barcelona (SPAIN)
- Rodríguez-Rodríguez C., Arsequell G., González-Duarte, P., València G. Nuevos quelantes como agentes de diagnóstico en la enfermedad de Alzheimer. 4ª Reunión Científica de Bioinorgánica (Real Sociedad Española de Bioinorgánica), September 2005, Calella (Barcelona, SPAIN)
Awards
- First Poster Award at the 13th International Conference on Biological Inorganic Chemistry (ICBIC13), July 2007, Vienna (Austria)
- First Poster Award at the 4ª Reunión Científica de Bioinorgánica, September 2005, Calella (Barcelona, Spain)
Languages
- Catalan - mother tongue
- Spanish - second mother tongue (bilingual native )
- English - high
Other interests
My favorite non-professional activities are playing the piano and mountain hiking. I like travelling and making new friends. Furthermore, I love collaborating in different activities for bringing science to people. Within this context, I have performed fun chemistry experiments in the Universitat Autònoma de Barcelona in order to motivate young people in science.
Moreover, I have collaborated in ‘Researcher’s Night 2008’ (http://stark.udg.edu/rn08/eng/) and participated as assistant chemist during the ‘Magic Show’ of Prof. Rudi van Eldik in Barcelona (photographies available in http://www2.iec.cat/FotografiesWeb/HomMendeliev/).
Moreover, I have collaborated in ‘Researcher’s Night 2008’ (http://stark.udg.edu/rn08/eng/) and participated as assistant chemist during the ‘Magic Show’ of Prof. Rudi van Eldik in Barcelona (photographies available in http://www2.iec.cat/FotografiesWeb/HomMendeliev/).
Entrades
